Fentanyl is a powerful synthetic opioid drug which is approximately 100 times more powerful than morphine (source: Janssen Pharmaceuticals Canada).

It is commonly used legitimately as an anesthetic in hospitals or for long-term pain management in the form of prescription Fentanyl patches.

It is also used in veterinary applications for sedation and general anesthesia.

Fentanyl and its analogues are listed as a schedule I drug under the Controlled Drugs and Substances Act in Canada.

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Fentanyl has become very popular in the sales of illicit street drugs as either a cutting agent or direct substitution for heroin or in the manufacturing of counterfeit Oxycodone pills.

Other illicit drugs such as cocaine and methamphetamine have been found to contain Fentanyl or a Fentanyl analogue. This may be an intentional mix on the part of the drug trafficker or may be as a result of an accidental cross contamination as the drug trafficker may be selling Fentanyl and other illicit drugs.








© Calgary Police Service

The numbers above have been compiled by the BC Coroners Service for Fentanyl detected deaths in British Columbia up to April 30, 2017


Fentanyl detected deaths have dramatically increased over the past few years with the significant increase in illicit Fentanyl making its way to the street. These detected deaths have been most profoundly identified in western Canada such as British Columbia and Alberta but are now increasing substantially across the country as more and more illicit Fentanyl makes its way to the recreational drug market.

Median lethal dose – LD50

The “median lethal dose” (LD50) is a term used as a general indicator of a substance’s acute toxicity. LD50 refers to the dose required to kill half the subjects of a test population. The lethal dose of any substance can vary with the subject depending on size, weight, sex, tolerance for regular exposure. Many illicit drugs have LD50 rates that are based on studies conducted on laboratory animals.


Fentanyl Patches

  • Typically contain between 2.5 mg and 10 mg of Fentanyl per patch with the dosage being slowly released over a length of time as identified on the packaging.
  • Recreational drug users are able to open these patches and extract the Fentanyl inside.
  • Fentanyl patches are not being seen as a source for significant volumes of illicit Fentanyl other than for personal users.
  • There have been occurrences of counterfeit Fentanyl patch production identified in eastern Canada where the abuses of Fentanyl patches are more common than in western Canada
Fentanyl 72 Hour Transdermal Patch
© Calgary Police Service

CDN 80 Pills

If you encounter green pills with “CDN” stamped on one side and “80” on the other, these are very likely counterfeit OxyContin.

Oxycodone Tablet
Oxycodone Tablet
Counterfeit Oxycodone Tablet - Green Throughout
Counterfeit Oxycodone Tablet - Green Throughout
Counterfeit Oxycodone Tablet - White Center

Oxycodone is a powerful semisynthetic opioid drug that has been used to treat moderate to severe acute or chronic pain under the name of OxyContin. One of the most common forms of Oxycodone in Canada has been the green “CDN 80” tablet which has the letters “CDN” stamped on one side and the “80” on the other side indicating the milligram size of the tablet. These tablets have been diverted or stolen and sold on the street for recreational drug users. Due to the issue of these pills being misused and abused by recreational drug users, the company producing them, Purdue Pharma, discontinued the production of this form Oxycontin in 2012.

Since the removal of the legitimate Oxycontin “CDN 80” tablet, illicit drug traffickers have begun to manufacture counterfeit “CDN 80” tablets using Fentanyl as the active ingredient inside these tablets. A number of Fentanyl analogues as well as other potent synthetic opioids have been found during analysis of these counterfeit tablets.

Originally these counterfeit tablets were found to be a solid color throughout similar to an MDMA tablet, that were easily identifiable to recreational drug users when the pill is split into two as the pharmaceutical version of the “CDN 80” tablet had a green coating but white inside. Over the past few years, illicit drug producers have increased the quality and counterfeit appearance of these counterfeit “CDN 80” tablets to exactly mimic the correct green color exterior and white interior to match that of the now discontinued “CDN 80” tablet.

Other Forms of Fentanyl

You might find illicit Fentanyl in other forms such as blotter paper or liquid.

Carfentanil Paper
© Winnipeg Police
Liquid Fentanyl
© Hamilton Police
Liquid Fentanyl
© Hamilton Police


Pill press machines used in the production of counterfeit Oxycodone tablets are high quality and pharmaceutical-grade.

Pill press machines like the one in the photograph are capable of producing 10,000 to 18,000 tablets per hour.




As the pure Fentanyl used in counterfeit heroin or counterfeit Oxycodone pills is so potent, the improper mixing of Fentanyl by drug traffickers can easily lead to batches of pills with ‘hot spots’. These batches of counterfeit Oxycodone pills may then be distributed in a specific geographic area and result in an increased number of overdoses/deaths in that area.


Through the analysis of illicit drug samples containing Fentanyl, it has been identified that the vast majority of Fentanyl submissions are identified to have not originated from pharmaceutical grade Fentanyl sources. Given the slight reduction of purity levels of these samples, it has been identified that the source of the majority of the Fentanyl which is found in the illicit domestic drug trade is either sourced from drug laboratories overseas or through the production of Fentanyl in domestic clandestine drug laboratories within Canada.

The majority of Fentanyl presently being distributed in Canada in the illicit drug trade is believed to be produced in other countries such as China, and then smuggled into the country, most commonly through international mail and package distribution.

Domestic Fentanyl Production

There are a number of synthesis routes that may be used by an illicit clandestine drug producer to manufacture Fentanyl.


Unlike commercial methamphetamine and MDMA clandestine drug labs, those producing Fentanyl, given its extreme potency, are often significantly smaller in size. Many solvents used to produce Fentanyl are the same as other synthetic drug production; however their precursor materials are not ones that are used to manufacture methamphetamine or MDMA.

Any suspected Fentanyl clandestine drug lab requires a response by law enforcement members with appropriate training and proper personal protective equipment.

Given the extreme potency of Fentanyl, these clandestine drug labs represent the highest risk of exposure to first responders, trained law enforcement clandestine lab investigators, and the general public.

The clean up and remediation of the locations where these clandestine labs are located is imperative to ensure that contamination does not remain present that could injure or potentially kill people who may be exposed to these locations.

Over the past few years, there has been a noted increase in domestic Fentanyl clandestine drug labs.


Fentanyl, its analogues, and other potent opioids high risk to first responders


A number of Fentanyl analogues have been identified by law enforcement across Canada. Analogues of Fentanyl can vary in potency / toxic properties depending on the chemical structure with some being less potent / toxic than Fentanyl and some being significantly more.

Definition of an analogue: a compound having a structure similar to that of another one, but differing from it in respect of a certain component (Wikipedia).

Fentanyl structure comparison versus 3-methylfentanyl:

The chemical structure of Fentanyl is extremely close to that of an analogue of Fentanyl, 3-methylfentanyl. However, 3-methylfentanyl is significantly more potent / toxic.

Fentanyl Structure
3-Methylfentanyl Structure

Analogues of Fentanyl such as Ohmefentanyl and Carfentanil are significantly more potent than Fentanyl. Carfentanil is approximately 10,000 times more powerful than a comparable dose of morphine versus Fentanyl at 100 times. (source: US Department of Justice Drug Enforcement Administration)


DEA Officer Safety Alert regarding Carfentanil

Due to the extreme potency of some analogues such as Carfentanil, these analogues have no legitimate medical use on humans. Carfentanil is only used legitimately as tranquilizer agent for large animals such as elephants.


4-chloro-N-[1-[2-(4-nitrophenyl)ethyl]-2-piperidinylidene]-benzenesulfonamide (referred to as W-18) is one of a series of compounds including W #1 – 32 compounds that produce analgesic effects (pain killer) similar to other potent opioid agonists such as Fentanyl and analogues of Fentanyl.

W-18 along with W-1 through W-32 was originally developed in 1982 but was never used for pharmaceutical purposes. Drug traffickers in Canada have used W-18 as a substitution for Fentanyl both in powder form and counterfeit Oxycodone tablets.

Recent testing and further research of W-18 has found that it does not bind to the opioid receptor and is an analgesic (pain killer).